Making (anti) Sense out of AAV vectors

Time: 9:45 am
day: Day Two


    • Competing platforms for AAV manufacturing
    • Plasmid-derived AAV vectors have co-packaged DNA contaminants
    • DNA contaminants lead to backbone-derived antisense RNAs
    • dbDNA as an alternative starting material
    • dbDNA eliminates plasmid backbone sequences, leads to improved vector purity and potency